Reference
SRSCIENT
Type
Permanent
Location
Oxford
Salary
£40k - £50k per annum
Category
Research & Development
Sector
Pharmaceuticals / Biotechnology / FMCG

ABOUT THIS ROLE

Northreach are working with an exciting Life Sciences company, based in Oxford, who are looking for a target identification and validation Senior Scientist with a background in tumour metabolism to explore metabolites and metabolic pathways that are present in cancer cells.

KEY RESPONSIBILITIES

We are looking for someone to help to build an understanding of how metabolic pathways in tumours shape the expression of metabolites that may be targets for company’s tumour-specific T cell receptors and support the Ligand Discovery Team with your knowledge to help identify and validate novel targets.

This is an opportunity for an innovative scientist to be a key part of a team striving to develop novel, impactful TCR therapies for cancer patients. As a Senior Scientist you will be a key part of a team working on several high impact areas of research within the Ligand Discovery team to identify and characterise targets for T cell receptors. These data will drive the development of biologics and cell therapies to make a meaningful difference for patients suffering from cancer. You will be responsible for:

  • Designing conducting and evaluating experiments using gene editing tools and technologies to validate metabolic pathway biology
  • Developing and utilising pharmacological cell-based or biochemical screening assay platforms.
  • Working closely with other research functional teams (e.g., Bioinformatics, Metabolomics and Immunopeptidomics) to validate the role of novel T cell antigens and cognate T cell receptors in cancer. This work will form the basis of T cell therapies for cancer
  • T cell profiling for very low frequency cells (use of Elispot, multimers), FACS sorting/analysis, CTL cloning, cytokine production (ELISA/TR-FRET) and recombinant T cell receptor expression/characterization.
  • Killing assays using flow and electrical impedance-based methodology. Minimum Qualifications and Experience required

 

The Ideal Candidate

Minimum Qualifications and Experience required:

  • Proven experience of working with gene editing techniques ideally in a biotech or academic setting (minimum of 3 years)
  • A PhD in a relevant scientific discipline, expertise with T-cell immunology preferred.
  • Proven experience of developing pharmacological cell-based or biochemical screening platforms and cancer metabolism desirable
  • Experience of managing and mentoring other scientists

The company offers a competitive salary, commensurate with qualifications and experience and a benefits package including pension and health insurance.

 

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