About the Role
Northreach is currently working with an exciting and well funded Biotech based in Oxford who is currently looking for a Principal Scientist to join their Cellular Immunology group.
As a Principal Scientist, you will support their efforts in the Cellular Immunology group to identify the most immunogenic antigens to identify optimal antigens for targeting with T-cell receptors, vaccines, or other modalities. You will also be part of the selection and characterisation of the most effective T-cell receptors for further development. This data will drive the development of biologics and cell therapies to make a meaningful difference for patients suffering from cancer.
What will you be doing
- Designing, conducting and evaluating experiments to establish the efficacy of T-cell receptors against novel cancer antigens. Developing and troubleshooting assays for T-cell functions
- T-cell profiling for very low frequency cells (use of Elispot, multimers), FACS sorting/analysis, CTL cloning and recombinant T-cell receptor expression/characterization. Killing assays using flow and electrical impedance-based methodology
- Establishment of robust T-cell expansion protocols for clinical application
- Actively contributing to a vibrant and innovative working environment where improvements and new ideas are adopted and freely shared among the teams
- Providing scientific coaching and mentorship for less experienced scientists in the team, as well as other scientists in our matrixed environment
- Providing expert technical direction, challenge and problem solving in projects
- Working closely with other research functional teams (e.g. Bioinformatics and Immunopeptidomics) to validate the role of novel T-cell antigens and cognate T-cell receptors in cancer. This work will form the basis of T-cell therapies for cancer
Minimum Qualifications and Experience required
- A PhD in a relevant scientific discipline, strong expertise in immunology preferred
- Strong experience in scientific and leadership roles preferably within biopharma companies, including experience working to develop cell-based therapies
- Proven experience of relevant immunological laboratory techniques (Flow cytometry essential)